Clinical Features, Surgical Treatment, and Long-Term Outcome in Pediatric Patients with Moyamoya Disease in China Xiang-Yang Bao Lian Duan Wei-Zhong Yang De-Sheng Li Wei-Jian Sun Zheng-Shan Zhang Rui Zong Cong Han

Background: There was few detailed demographic and clinical data about Chinese patients with moyamoya disease. Here we describe the clinical features, surgical treatment, and long-term outcome of pediatric patients with moyamoya disease at a single institution in China. Methods: Our cohort included 288 pediatric patients with moyamoya disease. The demographic and clinical characteristics were obtained by retrospective chart review and long-term outcome was evaluated using the stroke status. Univariate and multivariate logistic regression analyses were performed to determine the risk factors for clinical outcome. The risk of subsequent stroke was determined using the Kaplan-Meier method. Results: The median age for the onset of symptoms was 8.0 years. The ratio of female to male patients was 1: 1. Familial occurrence of moyamoya disease was 9.4%. The incidence of postoperative complications was 4.2%. Postoperative ischemic events were identified as predictors of unfavorable clinical outcome, while older age of symptom onset was associated with a favorable clinical outcome. The KaplanReceived: June 24, 2014 Accepted: November 3, 2014 Published online: January 6, 2015 Lian Duan Department of Neurosurgery, 307 Hospital, PLA The Center for Cerebral Vascular Disease 8 Dong-Da Street, Fengtai District, Beijing 100071 (China) E-Mail duanlian307 @ sina.com © 2015 S. Karger AG, Basel 1015–9770/15/0392–0075$39.50/0